TIRZEPATIDE

GLP-1
GIP
$299.00

Tirzepatide + B12 is a once-weekly injectable medication formulation that targets both GLP-1 and GIP receptors to support blood sugar regulation, enhance insulin sensitivity, and promote weight loss. It helps reduce appetite, slow gastric emptying, and improve metabolic flexibility, making it one of the most effective tools for long-term fat loss and metabolic health support. This formulation is compounded with B12, for a total vial content of 20mg Tirzepatide + 4mg B12 (labeled as 5mg Tirzepatide + 1mg B12 per 0.5mL in a 2mL vial). Note: Compounded with B12 for enhanced energy, metabolic support, and reduced injection site discomfort. The pink color is normal.

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MECHANISM OF ACTION
Tirzepatide activates the GLP-1 and GIP pathways to regulate glucose levels, suppress appetite, delay gastric emptying, and stimulate insulin secretion. The dual action increases energy efficiency and reduces fat storage while promoting satiety and metabolic reprogramming.
  • Increased weight loss and reduced visceral fat
  • Improved blood glucose and insulin sensitivity
  • Appetite suppression and reduced food cravings
  • Cardiometabolic protection and inflammation reduction
  • Improved energy, satiety, and long-term metabolic regulation
TOTAL CONTENT
20mg Tirzepatide + 4mg B12
CONCENTRATION
5mg/1mg/0.5ml
VIAL SIZE
2ml
SUPPLY
8-16 weeks (dose dependent)
STORAGE
Refrigerate at 36–46°F (2–8°C). Do not freeze.
  • Mild injection site redness or discomfort
  • Nausea, constipation, or diarrhea (common early)
  • Decreased appetite or food aversion
  • Vomiting or delayed gastric emptying (rare)
  • Active cancer
  • Pregnancy or breastfeeding
  • Known hypersensitivity to any medication components

This therapy should be used under the guidance of a healthcare provider. If you experience any of the following, discontinue use and contact us immediately:

  • Severe swelling or injection site reaction
  • Fever >100.4°F (38°C)
  • Fatigue that worsens over time
  • Signs of pancreatitis, gallbladder pain, or severe nausea
  • Shortness of breath, chest tightness, or facial swelling
  • Persistent GI symptoms prevent eating or hydration

HOW TO INJECT YOUR MEDICATION

STEP-BY-STEP GUIDE

Follow our comprehensive guide to ensure proper injection technique. This step-by-step process will help you maximize results and minimize discomfort. Follow the instructions carefully to ensure a safe and effective experience.

Wash your hands

STEP 1

Wash Your Hands

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STEP 1

Wash Your Hands

Wash thoroughly with warm water and soap. Dry with a clean towel.

Prepare the vial

STEP 2

Prepare the Vial

STEP 2

Prepare the Vial

If it's the first use of the vial, remove the plastic cap

Clean the rubber stopper with a fresh alcohol wipe

Let it air dry - do not blow on it

Draw solution

STEP 3

Draw Your Dose

STEP 3

Draw Your Dose

Use a new insulin syringe.

Insert needle into vial.

Turn vial upside down, draw your units following your dosing instructions.

Withdraw syringe.

Prep injection site

STEP 4

Prep Injection Site

STEP 4

Prep Injection Site

Choose a subcutaneous area (abdomen or upper glute).

Wipe the site with alcohol and let it dry.

Injection site diagram
Inject the medication

STEP 5

Inject the Medication

STEP 5

Inject the Medication

Pinch the skin to grab subcutaneous fat.

Insert needle at 90°.

Push plunger slowly and steadily.

Remove needle and apply gentle pressure.

First Week: Separate Injections

During your first week, inject each medication individually. This allows your body to gradually adapt to the new compounds and helps you isolate each medication's effects to better understand how your body responds.

Critical Safety Rule:

Always use a new sterile needle for every injection. Once a needle has entered your skin, it is no longer sterile - reusing it can introduce bacteria or trace blood into another vial, risking contamination, infection, or vial spoilage.

Example:

  • Draw Medication A → Inject → Discard syringe
  • Draw Medication B → Inject → Discard syringe
Rotate Injection Sites

Rotate injection sites and/or body regions to prevent irritation or scar tissue. For example, rotate between left/right sides of abdomen with left/right sides of upper glute.

Proper Storage

Medications can safely stay out of the fridge for up to 7 days, but they should be refrigerated as much as possible to maintain potency.

Sterile Equipment

Never reuse needles or syringes. Always use fresh, sterile equipment for each injection to prevent contamination and infection.

Timing Consistency

Inject around the same time each day for consistency and optimal results. This helps maintain stable medication levels in your body.

Normal Side Effects

Mild redness, itchiness, tenderness, or bruising can be normal. These typically resolve on their own within a few days.

Injection Site Bumps

Small bumps may form after injecting - this is just the fluid entering the tissue and will resolve on its own. No need for concern.

HOW TO INJECT YOUR MEDICATION

VIDEO GUIDE

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© 2026 The Protocole. All rights reserved. The Protocole facilitates access to telehealth services provided by licensed healthcare professionals. Prescription medications are available only following an appropriate clinical evaluation and when prescribed. Compounded medications are not FDA-approved. Individual results vary.

© 2026 The Protocole. All rights reserved. The Protocole facilitates access to telehealth services provided by licensed healthcare professionals. Prescription medications are available only following an appropriate clinical evaluation and when prescribed. Compounded medications are not FDA-approved. Individual results vary.

© 2026 The Protocole. All rights reserved. The Protocole facilitates access to telehealth services provided by licensed healthcare professionals. Prescription medications are available only following an appropriate clinical evaluation and when prescribed. Compounded medications are not FDA-approved. Individual results vary.

A PROTOCOLE. NOT A TREND.
A PROTOCOLE. NOT A TREND.
A PROTOCOLE. NOT A TREND.